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Faculté de pharmacie

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La page que vous consultez correspond à l'offre de formation 2023-2024.

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Pharmacogenetics

  • Cours (CM) 8h
  • Cours intégrés (CI) -
  • Travaux dirigés (TD) 4h
  • Travaux pratiques (TP) 20h
  • Travail étudiant (TE) -

Langue de l'enseignement : Anglais

Description du contenu de l'enseignement

Lectures content:
- types of genetic variability
- genetic variability and individual response to drugs (pharmacogenetics)
- new genotyping approaches to identify genetic variation (including new generation sequencing)

Practicals:
- Genomic DNA extraction from buccal cells and purification on a mini silica column
- Quantitative and qualitative characterization of genomic DNA by NanoDrop absorption spectrophotometry and Qubit spectrofluorometric measurements
- Genotyping reaction to search for Single Nucleotide Polymorphisms (SNP) -like polymorphisms affecting drug metabolism: use of pre-developed TaqMan-based assays for SNPs in genes encoding P450 cytochromes

Compétences à acquérir

Objectives in terms of knowledge:
Provide the student with knowledge allowing him:
- to understand the importance of genetic variations in drug development and use
- to apprehend current technological developments used to identify genetic variations
Objectives in terms of practical skills:
Perform genotyping of genetic variations and data analysis.

Objectives in terms of acquired skills:
Ability to:
- cite the different types of human polymorphism
- explain the principles of experimental methods used for genetic variation analysis presented during the course
- describe the importance of P450 cytochromes and polymorphism in their genes in differences in drug response between individuals
- establish, write and follow experimental protocols
- perform genotyping data analysis
- keep a laboratory notebook
- write a report in the form of a mini-publication (abstract, introduction, results and analysis, discussion and conclusion)
- present his/her experimental work orally using a PowerPoint presentation
 

Bibliographie, lectures recommandées

Scientific publications and other sources of information (protocols, websites) chosen by the teacher and illustrating the theme.
 

Contact

Faculté de pharmacie

74, route du Rhin - CS 60024
67401 ILLKIRCH-GRAFFENSTADEN
0368854110

Formulaire de contact

Responsable

Maria Zeniou-Meyer


MASTER - Biotechnologies

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